نتایج جستجو برای: dextran microspheres

تعداد نتایج: 21170  

2002
Glen S. Kwon Harry Cremers Jan Feijen Sung Wan Kim

Hydrophilic microspheres based on albumin-heparin conjugates have been prepared as a macromolecular delivery system. The soluble albumin-heparin conjugate was synthesized and crosslinked in a water-in-oil emulsion with glutaraldehyde to form microspheres in the same manner as for albumin microsphere preparation. The microspheres were characterized in terms of their size and swelling properties....

Journal: :iranian journal of basic medical sciences 0
mohsen tafaghodi school of pharmacy, mashhad university of medical sciences, mashhad, iran nanotechnology research center, mashhad university of medical sciences, mashhad, iran maryam eskandari school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s) the immunoadjuvant potential of cross-linked dextran microspheres (cdm) as absorption enhancer and quillaja saponins (qs) as immunomodulator adjuvant was evaluated. materials and methods cdm loaded or tetanus-mixed toxoid (tt) or quillaja saponin (qs) were nasally administered to rabbits in dry powder form, three times in 2 weeks interval and serum igg and nasal lavage siga titers ...

Journal: :International Journal of Nanomedicine 2007
Henk-Jan van Manen Aart A van Apeldoorn Ruud Verrijk Clemens A van Blitterswijk Cees Otto

Micro- and nanospheres composed of biodegradable polymers show promise as versatile devices for the controlled delivery of biopharmaceuticals. Whereas important properties such as drug release profiles, biocompatibility, and (bio)degradability have been determined for many types of biodegradable particles, information about particle degradation inside phagocytic cells is usually lacking. Here, ...

Journal: :the iranian journal of pharmaceutical research 0
faeze moghadam aryaee school of pharmacy, mashhad university of medical sciences, mashhad, iran mohsen tafaghodi school of pharmacy, mashhad university of medical sciences, mashhad, iran. pharmaceutical research center, mashhad university of medical sciences, mashhad, iran.

intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. however, soluble antigens (ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. so, in this study, tetanus toxoid ...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2017
Fei Wu Lili Dai Lee Geng Hua Zhu Tuo Jin

Using recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) as a model drug, the present study demonstrated a practically feasible process to produce polymeric microspheres for sustained-release delivery of protein drugs with preserved integrity. This process is featured with pre-loading proteins into polysaccharide fine particles via a self-standing aqueous-aqueous "emu...

Journal: :International journal of pharmaceutics 2004
Tae Hyoung Kim Tae Gwan Park

The cause of initial burst release of hydrophilic macromolecular drugs from biodegradable polymeric microspheres was identified. Poly(D,L-lactic-co-glycolic acid) microspheres encapsulating fluorescein isothiocyanate (FITC)-labled dextran was prepared by a double emulsion solvent evaporation method. The extent of initial burst release was examined by varying the formulation process conditions s...

Journal: :Journal of reproduction and fertility 1988
G D Moore H B Croxatto

Starch or dextran blue microspheres were transferred microsurgically to the infundibulum of the oviduct on Days 1, 2, or 3 of pregnancy of control and oestradiol-treated rats. The animals were killed a few hours to several days after transfer to assess the number and distribution of ova and microspheres in the tract. After transfer on Day 1 of pregnancy, microspheres and eggs crossed the ampull...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2005
Sophie R Van Tomme Bruno G De Geest Kevin Braeckmans Stefaan C De Smedt Florence Siepmann Juergen Siepmann Cornelus F van Nostrum Wim E Hennink

In this paper, the release of proteins from a novel self-gelling hydrogel based on biodegradable dextran microspheres is investigated. The protein-loaded macroscopic gels are obtained by hydration of mixtures of oppositely charged hydroxyethyl methacrylate-derivatized dextran microspheres with a protein solution. In media of low ionic strength (100 mM Hepes pH 7.0) it was found that the release...

Journal: :Plastic and reconstructive surgery 2004
Gottfried Lemperle Vera B Morhenn Vasumati Pestonjamasp Richard L Gallo

Injectable dermal filler materials consist of either fluids, biological fragments, or suspensions of particles or microspheres. Particles and microspheres are said to "migrate," but migration can occur only when they are injected into blood vessels. To evaluate biocompatibility and transport, five nonresorbable polymethylmethacrylate microspheres of various sizes, suspended in different carrier...

2009
Lianshan Li Ruiguo Cao Zhijian Wang Jingjian Li Limin Qi

Hierarchical, core-shell structured microspheres of bismuth chalcogenides (Bi2E3, E ) S, Se, Te) have been synthesized by chemical transformation of reactive precursor templates, which involves the formation of intermediate BiOCl mircrospheres and their subsequent hydrothermal transformation into Bi2E3 core-shell microspheres. The uniform precursor microspheres consisting of BiOCl nanoplates we...

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